About Us

Progress in biology is increasingly driven by revolutions within molecular biology measuring cellular material at an unprecedented scale. Consequently, biology is changing into a computational science, analysing and interpreting gigantic volumes of complex data. The Leiden Computational Biology Center (LCBC) focusses on this new approach to biology with the aim to generate new biological insights with clinical applicabilities. It brings together computational biologists that are skilled in the newest technologies in data science and molecular technologies. As molecular technologies are pushing the field towards more precise data (across all tissues and towards single cells), more diverse data (multi-omics), at both spatial and temporal resolution, fundamentally new computational models are required that go way beyond tools that handle the data (bioinformatics), and can model all these aspects integrally. These developments define the strategic research themes on which the LCBC focusses, being models geared towards (1) single cell data, (2) integrative data, and (3) spatio-temporal data. LCBC fosters modeling approaches for promising new molecular data into approaches that push biology boundaries. To realize this aim we work on long-term research projects in close collaboration with biologist and clinicians, and capitalize by proposing medical applications based on insights generated from research done within the LCBC.

LCBC is part of the Leiden University Medical Center.


News

  • Our collaborators from the Immunohematology and Blood Transfusion department at LUMC published their study showing that memory CD4+ T cells are generated in the human fetal intestine in Nature Immunology. The extensive study integrates data from several sources, such as Suspension Mass Cytometry, Imaging Mass Cytometry, RNA sequencing and TCR sequencing to paint a wholistic picture of CD4+...

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  • LCBC at SFN 2018
    9 Nov 2018

    Ahmed and Mandy attended the Society for Neuroscience Annual Meeting (Neuroscience 2018) in San Diego, California between 3 and 7 November. Mandy presented a poster on identifying gene expression signatures underlying stress resilience in the brain.

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  • LCBC at ECCB 2018
    14 Sep 2018

    LCBC was strongly present at ECCB2018. Marcel, Ahmed, Arlin, and Tamim represented LCBC at ECCB2018, taking place in Athens, Sep 8 to 12 this year. Arlin presented a poster on her work on identifying gene expression patterns correlated to Parkinson’s disease progression (unpublished work) and Tamim presented his method for automatic identification of cell types in mass cytometry...

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