Brain Transcriptome Atlases: A Computational Perspective

Abstract: The immense complexity of the mammalian brain is largely reflected in the underlying molecular signatures of its billions of cells. Brain transcriptome atlases provide valuable insights into gene expression patterns across different brain areas throughout the course of development. Such atlases allow researchers to probe the molecular mechanisms which define neuronal identities, neuroanatomy, and patterns of connectivity. Despite the immense effort put into generating such atlases, to answer fundamental questions in neuroscience, an even greater effort is needed to develop methods to probe the resulting high-dimensional multivariate data. We provide a comprehensive overview of the various computational methods used to analyze brain transcriptome atlases.

Ahmed Mahfouz, Sjoerd Huisman, Boudewijn Lelieveldt, and Marcel Reinders. Brain Transcriptome Atlases: A Computational Perspective. Brain Structure and Function, 222: pp. 1–24, 2016.
@article { bib:2017_bsaf_review,
author = { Ahmed Mahfouz and Sjoerd Huisman and Boudewijn Lelieveldt and Marcel Reinders },
title = { Brain Transcriptome Atlases: A Computational Perspective },
journal = { Brain Structure and Function },
volume = { 222 },
pages = { 1 -- 24 },
year = { 2016 },
doi = { 10.1007/s00429-016-1338-2 },
Brain Transcriptome Atlases screenshot