Eleven Grand challenges in single-cell data science

Abstract: The recent boom in microfluidics and combinatorial indexing strategies, combined with low sequencing costs, has empowered single-cell sequencing technology. Thousands-or even millions-of cells analyzed in a single experiment amount to a data revolution in single-cell biology and pose unique data science problems. Here, we outline eleven challenges that will be central to bringing this emerging field of single-cell data science forward. For each challenge, we highlight motivating research questions, review prior work, and formulate open problems. This compendium is for established researchers, newcomers, and students alike, highlighting interesting and rewarding problems for the coming years.

David Laehnemann, Johannes Köster​, Ewa Szczurek, Davis J McCarthy, Stephanie C Hicks, et al. Eleven Grand challenges in single-cell data science. Genome Biology, 2020.
@article { bib:2019_singlecellchallenges,
author = { David Laehnemann and Johannes K{\"o}ster​ and Ewa Szczurek and Davis J McCarthy and Stephanie C Hicks and Mark D Robinson and Catalina A Vallejos and Niko Beerenwinkel and Kieran R Campbell and Ahmed Mahfouz and Luca Pinello and Pavel Skums and Alexandros Stamatakis and Camille Stephan-Otto Attolini and Samuel Aparicio and Jasmijn Baaijens and Marleen Balvert and Buys de Barbanson and Antonio Cappuccio and Giacomo Corleone and Bas Dutilh and Maria Florescu and Victor Guryev and Rens Holmer and Katharin Jahn and Thamar Jessurun Lobo and Emma M Keizer and Indu Khatri and Szymon M Kiełbasa and Jan O Korbel and Alexey M Kozlov and Tzu-Hao Kuo and Boudewijn Lelieveldt and Ion I Mandoiu and John C Marioni and Tobias Marschall and Felix M{\"o}lder and Amir Niknejad and Łukasz Rączkowski and Marcel Reinders and Jeroen de Ridder and Antoine-Emmanuel Saliba and Antonis Somarakis and Oliver Stegle and Fabian J Theis and Huan Yang and Alex Zelikovsky and Alice C McHardy and Benjamin J Raphael and Sohrab P Shah and Alexander Sch{\"o}nhuth​ },
title = { Eleven Grand challenges in single-cell data science },
journal = { Genome Biology },
year = { 2020 },
doi = { doi.org/10.1186/s13059-020-1926-6 },
Single cell data science challenges screenshot